Search on: NITRATE VASODILATOR, ENDOGENOUS 
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Descriptor English:   Nitric Oxide 
Descriptor Spanish:   Óxido Nítrico 
Descriptor Portuguese:   Óxido Nítrico 
Synonyms English:   Endogenous Nitrate Vasodilator
Mononitrogen Monoxide
Nitric Oxide, Endothelium-Derived
Nitrogen Monoxide
Endothelium-Derived Nitric Oxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
Oxide, Nitric
Vasodilator, Endogenous Nitrate  
Tree Number:   D01.339.387
D01.625.550.500
D01.625.700.500
D01.650.550.587.600
Definition English:   A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. 
Pharmacological Action:   Bronchodilator Agents
Endothelium-Dependent Relaxing Factors
Free Radical Scavengers
Gasotransmitters
Neurotransmitter Agents
 
See Related English:   Endothelium-Dependent Relaxing Factors
Nitric Oxide Donors
 
History Note English:   1965 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   9753 
Unique Identifier:   D009569 

Occurrence in VHL: 		 

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